Dr. Robert Langdon (Tom Hanks, Forrest Gump) and cryptologist Sophie Neveu (Audrey Tautou, Amelie) set out to uncover the truth about The Holy Grail, encountering a mysterious ancient society on the way.
Harvard symbologist Robert Langdon is on business in Paris when he is called to the Louvre, where a curator he was due to meet has been murdered. There he meets police cryptologist Sophie Neveu, the granddaughter of the murdered curator. A number of symbols and riddles have been found at the murder scene and the duo set about solving the complex mystery. However, Bezu Fache (Jean Reno, Leon), the police officer in charge of the investigation believes that Langdon is implicated in the killing. This leads to Langdon being chased by the French police as he attempts to solve the mystery by following secret clues found in the works of artist Leonardo Da Vinci.
Langdon and Neveu escape to England to continue their search for clues in the mystery that has the possibility to upset the very foundations of Christianity, a search that brings them into conflict with Catholic organisation Opus Dei and their dangerous monk Silas (Paul Bettany, Gangster No. 1).