Now living like a hermit and wrangling rattlesnakes in Thailand, Rambo is drawn back into the action by a group of missionaries who want the taciturn, possibly psychotic, Vietnam vet to ferry them upriver into Burma. Though he initially proves reluctant 'Burma's a warzone. Sarah, played by Julie Benz, convinces Rambo of their noble intentions. Does he want to relieve suffering and stop ethnic cleansing? But when the group of idealists gets captured by the Burmese army, it's up to Rambo and a team of multinational mercenaries to save the day.
What follows is an exhilarating, hypnotic explosion of violence as Rambo fights genocide with genocide, destroying men with high-powered machine guns, well-placed bombs, razor-sharp machetes and the most deadly weapon of all, his bare hands.